USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: UBA1_HUMAN USC-OGP 2-DE database:  UBA1_HUMAN UBA1_HUMAN General information about the entry View entry in simple text format Entry name UBA1_HUMAN Primary accession number P22314 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Ubiquitin-like modifier-activating enzyme 1; EC=6.2.1.45 {ECO:0000305|PubMed:1447181}; AltName: Full=Protein A1S9; AltName: Full=Ubiquitin-activating enzyme E1;. Gene name Name=UBA1 Synonyms=A1S9T, UBE1 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1101: pI=5.44; Mw=126814 Cross-references UniProtKB/Swiss-Prot P22314; UBA1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name UBA1_HUMAN Primary accession number P22314 Secondary accession number(s) Q5JRR8 Q96E13 Sequence was last modified on  October 25, 2002 (version 3) Annotations were last modified on  March 15, 2017 (version 195) Name and origin of the protein Description RecName: Full=Ubiquitin-like modifier-activating enzyme 1; EC=6.2.1.45 {ECO:0000305|PubMed:1447181}; AltName: Full=Protein A1S9; AltName: Full=Ubiquitin-activating enzyme E1; Gene name Name=UBA1 Synonyms=A1S9T, UBE1 Encoded on Name=UBA1; Synonyms=A1S9T, UBE1 Keywords 3D-structure; Acetylation; Alternative initiation; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Ligase; Mitochondrion; Neurodegeneration; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Ubl conjugation; Ubl conjugation pathway. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X56976; CAA40296.1; -; mRNA EMBL M58028; AAA61246.1; -; mRNA EMBL AL513366; CAI41708.1; -; Genomic_DNA EMBL CH471164; EAW59290.1; -; Genomic_DNA EMBL BC013041; AAH13041.1; -; mRNA EMBL X52897; CAA37078.1; -; mRNA CCDS CCDS14275.1; -. [P22314-1]; . PIR A38564; A38564; . RefSeq NP_003325.2; NM_003334.3. [P22314-1]; . RefSeq NP_695012.1; NM_153280.2. [P22314-1]; . RefSeq XP_016885269.1; XM_017029780.1. [P22314-1]; . RefSeq XP_016885270.1; XM_017029781.1. [P22314-1]; . UniGene Hs.533273; -; . PDB 4P22; X-ray; 2.75 A; A/B=1-439 PDBsum 4P22; -; . ProteinModelPortal P22314; -; . SMR P22314; -; . BioGrid 113165; 137; . DIP DIP-33686N; -; . IntAct P22314; 122; . MINT MINT-1130980; -; . STRING 9606.ENSP00000338413; -; . BindingDB P22314; -; . ChEMBL CHEMBL5924; -; . DrugBank DB04119; Hexatantalum Dodecabromide; . iPTMnet P22314; -; . PhosphoSitePlus P22314; -; . SwissPalm P22314; -; . BioMuta UBA1; -; . DMDM 24418865; -; . REPRODUCTION-2DPAGE IPI00645078; -; . EPD P22314; -; . MaxQB P22314; -; . PaxDb P22314; -; . PeptideAtlas P22314; -; . PRIDE P22314; -; . DNASU 7317; -; . Ensembl ENST00000335972; ENSP00000338413; ENSG00000130985. [P22314-1]; . Ensembl ENST00000377351; ENSP00000366568; ENSG00000130985. [P22314-1]; . GeneID 7317; -; . KEGG hsa:7317; -; . UCSC uc004dhj.5; human. [P22314-1]; . CTD 7317; -; . DisGeNET 7317; -; . GeneCards UBA1; -; . GeneReviews UBA1; -; . HGNC HGNC:12469; UBA1; . HPA CAB019435; -; . HPA CAB073410; -; . HPA HPA000289; -; . HPA HPA001506; -; . MalaCards UBA1; -; . MIM 301830; phenotype; . MIM 314370; gene; . neXtProt NX_P22314; -; . OpenTargets ENSG00000130985; -; . Orphanet 1145; X-linked distal arthrogryposis multiplex congenita; . PharmGKB PA37119; -; . eggNOG KOG2012; Eukaryota; . eggNOG COG0476; LUCA; . GeneTree ENSGT00390000016689; -; . HOGENOM HOG000167329; -; . HOVERGEN HBG054199; -; . InParanoid P22314; -; . KO K03178; -; . OMA FISCESR; -; . OrthoDB EOG091G0130; -; . PhylomeDB P22314; -; . TreeFam TF300586; -; . BioCyc MetaCyc:HS05465-MONOMER; -; . BRENDA 2.3.2.B5; 2681; . BRENDA 6.2.1.B9; 2681; . Reactome R-HSA-8866652; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; . Reactome R-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation; . SIGNOR P22314; -; . UniPathway UPA00143; -; . ChiTaRS UBA1; human; . GeneWiki UBA1; -; . GenomeRNAi 7317; -; . PRO PR:P22314; -; . Proteomes UP000005640; Chromosome X; . Bgee ENSG00000130985; -; . CleanEx HS_UBA1; -; . ExpressionAtlas P22314; baseline and differential; . Genevisible P22314; HS; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0005829; C:cytosol; IDA:HPA; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005739; C:mitochondrion; IDA:UniProtKB; . GO GO:0005654; C:nucleoplasm; IDA:HPA; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0004839; F:ubiquitin activating enzyme activity; IDA:MGI; . GO GO:0006974; P:cellular response to DNA damage stimulus; IDA:UniProtKB; . GO GO:0016567; P:protein ubiquitination; TAS:Reactome; . Gene3D 1.10.3240.10; -; 1; . Gene3D 3.40.50.720; -; 4; . InterPro IPR032420; E1_4HB; . InterPro IPR032418; E1_FCCH; . InterPro IPR016040; NAD(P)-bd_dom; . InterPro IPR000594; ThiF_NAD_FAD-bd; . InterPro IPR018965; Ub-activating_enz_E1_C; . InterPro IPR019572; UBA_E1_Cys; . InterPro IPR018075; UBQ-activ_enz_E1; . InterPro IPR018074; UBQ-activ_enz_E1_CS; . InterPro IPR033127; UBQ-activ_enz_E1_Cys_AS; . InterPro IPR000011; UBQ/SUMO-activ_enz_E1-like; . Pfam PF16191; E1_4HB; 1; . Pfam PF16190; E1_FCCH; 1; . Pfam PF09358; E1_UFD; 1; . Pfam PF00899; ThiF; 2; . Pfam PF10585; UBA_e1_thiolCys; 1; . PRINTS PR01849; UBIQUITINACT; . SMART SM00985; UBA_e1_C; 1; . SUPFAM SSF69572; SSF69572; 2; . TIGRFAMs TIGR01408; Ube1; 1; . PROSITE PS00536; UBIQUITIN_ACTIVAT_1; 1; . PROSITE PS00865; UBIQUITIN_ACTIVAT_2; 1; .

Gateways to other related servers

• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
• World-2DPAGE Repository - A public repository for gel-based proteomics data linked to protein identification published in the literature.
• World-2DPAGE Portal - A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
• ExPASy - The resources web server of the Swiss Institute of Bioinformatics

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